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CADTH identified several areas of uncertainty to the sponsors analysis that have notable implications on the results of the BIA: Market share assumptions were considered uncertain: Due to limited data, the sponsor made assumptions regarding the future market share of oral semaglutide, including assuming | % market share would be taken from |, and |% will come from |||

Metformin comes as a tablet, extended-release tablet, and liquid solution, all of which are taken by mouth

Retatrutide holds no MHRA or EMA marketing authorisation as of 2026

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