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The HEIDI test manifested that the analyses of GLP1R with background DR ( P = 0.29), and severe nonproliferative DR ( P = 0.42) were not due to linkage

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The greatest improvements were seen in the triplet therapy arm, which combined semaglutide, trevogrumab, and garetosmab

Food and Drug Administration (FDA): Ozempic (semaglutide) Injection Prescribing Information National Institutes of Health (NIH): Gastrointestinal Side Effects of GLP-1 Receptor Agonists and Clinical Management The New England Journal of Medicine (NEJM): Effects of Semaglutide on Chronic Kidney Disease Progression in Patients with Type 2 Diabetes (The FLOW Trial) American Diabetes Association (ADA): Standards of Care in DiabetesMetabolic Strategies and Renal Safety Profile of Incretin-Based Therapies National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Understanding Acute Kidney Injury: Causes, Risks, and Fluid Balance Protocols

Second, the stability, pharmacokinetics and bioavailability of peptide drugs also need to be addressed to ensure that the drugs can effectively exert therapeutic effects in vivo