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Yan Y, Bazzano LA, Juonala M, et al
Presented for research literature review only Banihani SA et al
Smaller, evenly spaced meals often work better than large, infrequent ones, especially during dose escalation
We should note here that the preservation of weight loss and food intake inhibition by GIPR antagonism in mice with disturbed GIPR signalling in the PNS is not unexpected, given that mice with CNS loss of Gipr (thus, mimicking the use of an antagonist) show decreased body weight and food intake when fed a HFD 15 , suggesting that the reduction in body weight by GIPR antagonism is mediated by neurons of the central rather than peripheral nervous system
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