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Noticeable changes in face, waist, and clothing fit occur by week 4-8

Numbers are reported as research planning context, not a dosing recommendation

[4] [10] Data from a phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated that gastrointestinal side effects were among the most commonly reported adverse events with retatrutide, particularly at higher doses

The Latest Science About GLP-1 Drugs & Weight Loss Although GLP-1s aren't new (they've been used to treat diabetes for decades), new research continues to be published about them

Some strategies that help include timing your injection to precede your socially challenging days (inject Wednesday if weekends are your struggle), planning lighter meals specifically for days 5 through 7, and discussing split dosing with your provider to maintain more consistent levels