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This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis but also reveals a weight loss-independent repair mechanism that targets metabolic pathways and mediators essential to cartilage repair under osteoarthritis conditions, the study authors wrote

I add this both for my patients who are on GLP-1 or aren't

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A GLP-1 RA with proven cardiovascular benefit is recommended in patients with T2D who have albuminuric diabetic kidney disease (DKD) if a SGLT2 inhibitor is contraindicated or not tolerated