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Why brain-based GLP-1 activity matters clinically: It helps explain the appetite-suppressing effects of GLP-1 receptor agonist medications It may contribute to neuroprotective mechanisms being investigated in neurodegenerative diseases It potentially influences cognitive processes and mood regulation, though human evidence remains limited It provides insight into the gut-brain axis and metabolic-neurological interactions Understanding GLP-1's cerebral actions has become particularly relevant as GLP-1 receptor agonistsoriginally developed for type 2 diabetesare now also licensed for weight management in the UK (NICE TA875, TA664)
When that happens, bad outcomes can happen. Then there is the question of how long you microdose for and the long-term cost
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Furthermore, abiraterone plus abemaciclib was evaluated in a phase 2/3 trial, and ribociclib plus enzalutamide or docetaxel are under investigation in different trials for the treatment of mCRPC (Table 7)
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