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The single most significant driver for the GLP-1 receptor agonist market is the escalating global burden of obesity and metabolic syndrome

Semaglutide# Semaglutide has the most extensive GLP-1 evidence base: SUSTAIN (T2D injectable, 7 trials), PIONEER (T2D oral, 9 trials), STEP (obesity, multiple trials), and SELECT (cardiovascular outcomes, n=17,604, 20% MACE reduction)

Aroda VR, Faurby M, Lophaven S, Noone J, Wolden ML, Lingvay I

The purpose of this study was to investigate how vascular GLP-1 receptor expression is influenced in human subjects

Among the four patients who discontinued naltrexone-bupropion early within the first month, three of them discontinued due to side effects: one for disturbances in attention and palpitations, one for neurological symptoms (headache, dizziness, and vomiting), and one discontinued due to gastrointestinal side effects of bloating