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Unlike traditional protocols that begin at 0.25 mg weekly, microdosing may begin as low as 0.05 mg

We also included important information regarding recent FDA guidelines, which no longer allow the compounding of semaglutide and tirzepatide due to the availability of FDA-approved versions

also verified the beneficial effects of liraglutide on hepatic steatosis and inflammation in a HFD mouse model and hypothesized that these may be mediated by regulating ER stress, thus reducing apoptosis, in the pancreas and the liver [24]

Both preclinical and clinical studies support that the gastric slowing that occurs with tirzepatide is due to GLP-1R agonism and not related to GIPR agonism [15]