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Even more compelling is the finding that metformin essentially appeared to be as potent in lowering blood glucose levels in incretin receptor knockout mice as it did in wild-type mice
A true microdose might start at 0.125 mg or lower
The potent insulinotropic action of the gut incretin GLP-1 that induces satiety is considered to be at least partly mediated by sensory afferents innervating the gut, as sensory denervation by neonatal capsaicin administration in mice impaired insulinotropic effects of GLP-1 [6, 7]
How it compares to Mounjaro and Wegovy The most useful comparison is what the main Phase 3 trials of each medication have shown for weight loss in adults without type 2 diabetes
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