The American Association of Clinical Endocrinology (AACE) 2023 consensus statement on obesity management recommends selecting anti-obesity pharmacotherapy based on magnitude of weight loss needed, comorbidity profile, and insurance access
When your reconstituted retatrutide is at 5mg/mL and you want a 2mg dose: 2mg 5mg/mL = 0.4mL = 40 IU on the syringe Pull the plunger back until the black rubber tip aligns with the "40" mark When you're at 10mg/mL and want a 2mg dose: 2mg 10mg/mL = 0.2mL = 20 IU on the syringe Pull the plunger back until the black rubber tip aligns with the "20" mark Half-Unit Precision For small doses (0.5mg or 1mg), you'll be drawing very small volumes sometimes just 510 IU
This observation may explain why semaglutide and other GLP-1 RAs ranked among the lowest-impact DM2 DMTs in our model compared to drugs such as metformin, which engage a broader range of metabolic and neuroprotective pathways (e.g., AMPK, insulin, and adipocytokine signaling)
Good indicators you're ready to stack: You've found your stable Reta dose (typically 1-3mg weekly) GLP-1 side effects have subsided or are manageable Weight loss or body comp changes are proceeding as expected You want to accelerate visceral fat loss or improve training performance The Stacking Order: Tesamorelin First If you're adding both compounds, start with Tesamorelin: Week 1-2: Add Tesamorelin 1mg daily (evening injection, before bed) Week 3-4: Increase to 2mg daily if tolerated Week 5-6: Add MOTS-C 500mcg daily (morning, any time) Why Tesamorelin First Synergy with Reta's fat loss mechanisms
FDA states that LightEyez agreed to recall all the eye drops it was selling in the US, but has not done so