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Specification and emulation of the reference trial including our expansion studies are stated in the Supplementary Information, following the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline (Supplementary Tables 2729) 42

Granger analyses were calculated with Stata [81] and results were visualized with R [82]

Pushing the glucose too high can be counterproductive, as this can stimulate endogenous insulin release, leading to rebound hypoglycemia

Remember, GLP-1 RAs were designed to treat type 2 diabetes