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it addresses both the cellular trigger (oxidative stress in the mast cell) and the systemic clearance mechanism (hepatic detoxification)
In PsO, clinical studies evaluating GLP-1RAs such as liraglutide and semaglutide have reported significant improvements in PASI scores and histopathological skin features, effects that appear to be at least partially independent of weight loss ( Given the prominent role of IL-17driven inflammation in obese PsA patients, GLP-1RAs may also enhance the efficacy of biologic agents targeting these pathways
Engineering precision nanoparticles for drug delivery
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