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semaglutide improved kidney outcomes in people with type 2 diabetes and chronic kidney disease in FLOW. Joints and musculoskeletal tissue: Mechanical overload from excess weight can cause local pain and inflammatory signaling (often improving with weight reduction)
Target: 500 mcg daily by Week 5 and maintain through cycle completion
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Adding tesamorelin may provide incremental benefits for visceral fat and muscle preservation, but those benefits come with significant unknown risks
Lipid Profile What to Monitor: Total Cholesterol, LDL, HDL, Triglycerides Why It Matters: GLP-1 medications often dramatically improve cholesterol values independent of weight loss
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