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Thiol redox status regulate MPT and enhanced ROS generation can target critical cysteine residues in cyclophilin D, implying that mGSH depletion would favor MPT via redox pathways targeting MPT components

Both compounds have distinct safety profiles

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It is important to emphasize that although this meta-analysis brings promising data, there is a need for further research to confirm these findings and to better understand exactly how L-carnitine interacts with the mechanisms of diabetes