Ongoing trials Trials like NCT07328100 (intravenous coenzyme I for vascular aging, 2026 start) and NCT05243290 (oral NR in Gulf War Illness) continue to expand the human evidence base
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801 In mice with I/R injury, methylmalonic acid promotes the expression of NOX2/4, increases ROS production in cardiomyocytes, aggravates myocardial oxidative stress and ferroptosis, and expands myocardial infarction size and cardiac dysfunction