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Systemic human safety trials for injectable GHK-Cu are severely lacking, and the transition from topical cosmetic to systemic biologic introduces massive pharmacological variables
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Conditions That Increase Injection Site Discomfort Higher concentrations: At higher concentrations of GHK-Cu, the concentration of positively charged GHK-Cu molecules at the injection site increases, amplifying the localised pH disturbance and the associated discomfort
For a 5mg vial, 2-2.5mL is typical
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