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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

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In addition, the incidence and severity of psychiatric symptoms, as well as quality of life (QoL), were evaluated in both groups

Supplementary material The Supplementary Material for this article can be found online at: References 1 ChenJ.WangM.JoyceA.DeFrancoD.KavosiM.XuX.et al (2014)

The age-related changes are associated with a decrease in the levels of GH as people get older