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Both modifications are studied in vitro for the resistance they confer to exopeptidase cleavage and for their effect on measured peptide half-life in serum-stability assays
10.1146/annurev-biophys-070317-033239 68
No peer-reviewed research exists on the specific formulation
It is more likely at higher doses and during the first weeks of a new dose level
Some conditions do apply, but it is generally a very straightforward guarantee
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