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Gastrointestinal side effects are the most common, particularly when starting treatment or after a dose increase, and these usually improve over time

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Semaglutide with methylcobalamin has shown particular promise for addressing the B12 depletion that can occur during extended GLP-1 use

A GLP-1R polymorphism was linked to enhanced semaglutide response in females, hinting at sex-linked differences in receptor sensitivity [180]