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Additionally, proteolytic degradation is a major challenge in peptide-based therapeutics, as it results in short half-life, low bioavailability, rapid clearance, and ultimately reduced therapeutic efficacy
These often ease with slower titration
Some hunger may return, and weight regain is possible without supportive habits in place
Each dose level is maintained for at least 4 weeks before the next increase
The treatment led to substantial, sustained weight loss versus placebo and maintained improvements in cardiometabolic parameters
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