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How the Evidence Balances Heart Rate Changes against Cardiovascular Outcomes While semaglutide raises resting heart rate mildly, several trials report cardiovascular event benefits for GLP-1 receptor agonists as a class in people with established cardiovascular disease
N Engl J Med 2025;392:777-87.ArticlePubMed 118
Whilst early results are promising, retatrutide is not approved for clinical use , and any claims about its effects outside of peer-reviewed trial data should be viewed critically
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