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Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes

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This section briefly explores the main causes of eNOS uncoupling and their therapeutic implications (Figure 5)

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Watch for signs such as rash, itching, swelling, or trouble breathing

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One limitation of this approach is that medications with substantially different adverse event profiles may generate ratios that do not entirely capture their true visual impairment risk

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Microdosing may be considered for patients with coexisting conditions such as autoimmune disease, chronic pain, or other factors that warrant a gentler approach

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