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Stages in the development of Parkinsons disease-related pathology
Multiple systematic reviews and meta-analyses of randomized controlled trials indicate a favorable safety profile
it was previously approved in 2022 for treating type 2 diabetes
Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69
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