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The injected hydroxocobalamin is transported via the bloodstream to tissues throughout the body, where it acts as a cofactor for two critical enzymatic reactions: the conversion of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA
Adults need 2.4 micrograms (mcg) daily, with slightly higher amounts during pregnancy or chestfeeding
The NICE Clinical Knowledge Summary on B12 and folate deficiency recommends assessing the underlying cause before choosing a treatment path, which is why speaking to a pharmacist or GP first matters
Many researchers struggle with proper reconstitution techniques
After reconstitution with bacteriostatic water, the solution should be refrigerated at 2 to 8 degrees Celsius and used up within about 28 to 30 days
