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The shelf life rules are identical across brands, because they come from the product class rather than from any individual manufacturer

A study that looked at 0.5-1mg/kg/day leucovorin in patients with cerebral folate deficiency (and related neurological symptoms) found that 90% of those supplemented achieved normal 5-methyltetrahydrofolate cerebral spinal fluid concentrations

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Since they are not synthesized by the human body, except for niacin, they must be obtained through frequent dietary intake, since they are water-soluble (5)