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These highly potent molecules act as the immune system's "cleanup crew," actively signaling the microglial cells to stand down, halting the inflammatory cascade, and promoting the clearance of cellular debris

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Initially, semaglutide was used to manage type 2 diabetes by helping the body use insulin more effectively

Mass spectrometry and Edman degradation identified these proteins as the secretin PilQ (Table S2) and the pentapeptide repeat protein NIES39_A07680 65

Interestingly, while lysosomes in ACT-treated WT cells also display lysosomal acidification impairment, the lysosomal pH in ATP6AP1 KO cells remained unaffected by ACT treatment