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Characterized by insulin resistance, gradual progressive loss of insulin secretion by -cells, and being heavily driven by being overweight or obese [98], T2DM leads to hyperglycemia, excessive urine production, increased risk of cardiovascular disease, and changes in energy metabolism [106]
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Studies link taurine to better heart function and fewer arrhythmias
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Once intracellular lactate is sufficient to induce CD4 + T cell phenotype transformation, RORT-dependent IL-17 expression via activation of the PKM2-STAT3 axis would be initiated, confirming lactate as a critical mediator in inflammation-related diseases, including RA
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