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[9] For methylation-focused NNMT studies, stronger experimental designs may include SAM, SAH, SAM/SAH ratio, nicotinamide, 1-methylnicotinamide, NAD + , global DNA methylation, locus-specific DNA methylation, histone methylation markers, RNA expression profiling, and tissue-specific analysis where relevant
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Exercise performance: VO2 max proxies (pace at a given heart rate), strength output, and recovery speed between sessions are all relevant markers
DAC creates a constant, low-grade stimulus instead
Review the families, honest evidence, and safety gaps.
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