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The pooled phage output surviving PACE on PC_SS1 was next subjected to phage-assisted non-continuous evolution (PANCE) 52,53,54 on PC_SS2, which contained six additional mutations toward procaspase-1 (Fig
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Simultaneously, mitochondria release Smac/Diablo, HtrA2, and Arts, which promote apoptosis by inhibiting the X-linked inhibitor of apoptosis protein (XIAP) (Tower, 2015)
Regulatory pathway interaction and response
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