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The oral-contraceptive interaction is a separate study (GPGR), reported in the FDA Mounjaro NDA 215866 summary review: a single 5 mg tirzepatide dose with a combination oral contraceptive (0.035 mg ethinyl estradiol / 0.25 mg norgestimate) reduced the Cmax of norelgestromin and ethinyl estradiol by 55% to 59% a range spanning both analytes, not a separate figure for each with AUC lowered 28.8% (norelgestromin) and 27% (ethinyl estradiol), and tmax delayed 2.5 to 4.5 hours

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doi:10.1111/j.1574-6968.2012.02565.x

A pleasant taste and a rapid effect

It tells your pancreas to release insulin when sugar is in your blood, stops your liver from making too much sugar, slows how quickly food leaves your stomach, and signals your brain that you're full