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Long-term metformin use is generally well-tolerated, which is why it remains a first-line diabetes medication worldwide

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Therefore, in combination with vitamin status and methionine intake, this negative interaction between age and homocysteinemia might be taken into account in future epidemiologic studies, which should use age- and gender-specific reference ranges

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The medication must be titrated carefully because three receptor pathways mean three sets of biological effects to manage

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NSL literature pointer PMID 15557068 L-Carnitine laboratory index [PMID: 15557068] National Science Labs indexing note for PMID 15557068: review the PubMed methods, models, and limitations before citing

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