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The LEAD-3 study found that liraglutide monotherapy reduced glycosylated hemoglobin (A1C), body weight, and blood pressure compared to glimepiride (36)
This is particularly important with tirzepatide, which can reduce oral contraceptive exposure during initiation and dose escalation, potentially requiring backup contraception
The titration period for Zepbound extends 20 weeks to reach the maintenance dose
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