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GLP-1RAs improve hyperglycemia by enhancing insulin secretion through increases in -cell cytoplasmic cyclic adenosine monophosphate [53], which activates protein kinase A (PKA) and, thus, increases in intracellular calcium and triggers insulin exocytosis in a glucose-dependent manner [54]

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Mendler AN, Hu B, Prinz PU, Kreutz M, Gottfried E, Noessner E

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