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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
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Ethylenedibromide, a gasoline additive and a fumigant, is presumed to be potential human carcinogen because it is transformed by GSTs to DNAreacting episulfonium ion (van Bladeren, 2000)
Moreover, injecting plain water into the bloodstream can be dangerous: without solutes, it is not isotonic to human blood and can cause red blood cells to burst (hemolysis)
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