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To address this question, we used 70 kDa FITC-dextran, a larger molecule that can cross the barrier only in an unrestricted manner (in contrast to 4 kDa FITC-dextran which can pass via increased paracellular permeability 14 )
In a study involving 67 patients, DSIP treatment resulted in a beneficial effect in 48 out of 49 evaluable patients
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Without proper anatomical landmarks and sterile technique, you risk introducing bacteria into a synovial space where infection (septic arthritis) can destroy cartilage within 24-48 hours
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