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Studies of bariatric surgery and intensive lifestyle interventions have consistently shown that weight reduction of 5-10% or more can improve menstrual regularity and fertility in women with obesity
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The starting dose is 2.5 mg, and it is then gradually increased every 4 weeks to the maintenance dose as directed by your doctor, with a maximum dose of 15 mg
In these patients, administration of an NSAID may cause a dose-dependant reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal failure
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