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"We don't really know why some people only lose 5% where some people are super responders and losing 30% of their body weight." Kushner thinks of the result as a kind of new settling point the medication helps establish, though why it lands so much lower for some people isn't well understood
For patients on GLP-1 medications, preserving lean muscle is crucial to ensure that the weight lost comes primarily from fat, not muscle tissue
Typically, application of one 0.25mg dose once weekly for the first 4 weeks constitutes the standard initiation therapeutic dose for the restoration of physiological equilibrium
it starts at 2.5 mg once weekly and steps upward at approximately four-week intervals toward a maintenance target
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