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Moreover, the SURMOUNTMMO (tirzepatide, NCT05556512) will assess the impact of the dual GLP-1/GIP RA in cardiovascular outcomes and all-cause mortality for people with obesity (without diabetes) when the REDEFINE-3 study will assess the impact of cagrisema in people with obesity (with and without T2DM) and established cardiovascular disease
See Supplementary Note for rationale of using U46C GPX4
12 Stephens FB, Evans CE, Constantin-Teodosiu D, et al
10.1016/j.bbrc.2021.02.065 93 ZhangZ.MaY.XieC.HeY.WangD.SongH.et al (2025)
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