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CB-839 resistant breast cancer cell line (but not their parental cells) showed down-regulated glutamine consumption and requires exogenous asparagine in cell culture medium for proliferation, implying glutamine independence in cancer cells may be related to the switch to asparagine pathway in order to reach the cellular demand for survival [65]
Rohira, H., Arora, A., Kaur, P
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B12 is also involved in the synthesis of hormones and neurotransmitters
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