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It has never been approved as a standalone drug in any country, and Novo Nordisk is not pursuing it as a monotherapy
There is also the question of what happens when GLP-1 therapy is eventually stopped: weight tends to return, suggesting that the underlying biology of obesity has not been fundamentally altered
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AOD-9604 avoids these issues while still promoting fat metabolism and tissue repair
In oncology, a 2026 meta-analysis quantified this mismatch directly: Black cancer patients had an enrollment-to-incidence ratio of just 0.25 and Hispanic patients 0.51 , meaning both groups enroll in trials at roughly a quarter to a half of the rate their cancer incidence would predict ( [12] )
