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The incretin effect is reduced in people with T2DM, mainly because GIP has less of an impact [85]

Hydroquinone (HQ), another well-studied whitening agent, has been used clinically in leading cosmetic hyperpigmentation treatment 23 , however, it was also found to cause serious problems by generating reactive oxygen species leading to oxidative damage of lipids and permanent loss of melanocytes

This goes by the brand name Grifta, and it's an FDA approved drug for the reduction of visceral adiposity in HIV patients

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As newer therapies emerge, many individuals are beginning to question whether switching from semaglutide to tirzepatide might offer better outcomes