pbs tirzepatide SURPASS‑EARLY evaluated starting early in type 2 diabetes vs. conventional step-therapy. In adults with early T2D on metformin, tirzepatide produced larger 2‑year reductions in HbA1c, weight, and waist circumference than intensified Drug company rejects PBS funding

This dual activation results in enhanced insulin secretion and more significant reductions in glucagon levels compared to GLP-1 agonists alone

10.1111/j.1471-4159.2007.04837.x 33 FarooqueU.OkorieN.KatariaS.ShahS

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