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While the Cmax values observed on the first day for all hydrogel-based TZP and Sema formulations might be expected to cause nausea and suppressed food intake in rodents, no changes to animal behavior were observed throughout the study

[4] [5] These symptoms result from delayed gastric emptying and direct effects on the gastrointestinal tract

For many years after exenatides approval, GLP-1 receptor agonists were used primarily as diabetes medications

Osibogun, O., Ogunmoroti, O

Diet, microbiome and symptom context: Diet and microbiome factors can be relevant in selected patients, but they should be considered alongside clinical assessment rather than used as a replacement for evidence based IBD care