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Correspondingly, previously published data mentioned that 1 and 2 -ARs are either downregulated or desensitized, whereas the protein level of 3 -ARs upregulates in the mammalian heart under pathological conditions, including insulin resistance [35,36,37]

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And not all studies found the same link, so the evidence is mixed

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Leukemia 10(3):473-7, 1996