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In addition, in a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity, without affecting centrally regulated anxiety-like behaviors [56]
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A few years after these publications, a competing hypothesis was proposed, suggesting that the formation of reactive oxygen species (ROS) during the metabolism of APAP by cytochrome P450 enzymes results in extensive lipid peroxidation (LPO), which is responsible for cell death [11,12]
Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD (2014) Quantitative flux analysis reveals folate-dependent NADPH production
They signed a collaborative agreement to explore a different potential application for AOD-9604, one that veered away from weight loss and stepped into the realm of cosmetics
