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Pollak, M
TMAO can change the bile acid spectrum to accelerate the formation of aortic lesions in ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)
That's why many people are exploring glutathione IV therapy as a way to boost this critical molecule and support their health
Molecular Biology Reports , 46 (1), 12631274
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