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Interestingly, GLP-1RA drugs act on receptors that are expressed in brain areas involved in impulse control, reward and addiction potentially explaining their effectiveness in curbing appetite and addiction disorders, said Al-Aly, the director of the Clinical Epidemiology Center at the VA St

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In clinical trials, semaglutide produced average weight losses of 12% to 15% of body weight

However, downstream effects such as body composition changes, improved sleep quality, or visceral fat reduction typically require consistent administration over several weeks to months of research