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The median increase of vitamin B12 levels in the non-responder group was 97 pmol/l (IQR: 78, 173) and in the responder group 934 pmol/l (IQR: 571, 1130)

They are a critical, non-negotiable element

Extensive research has unequivocally highlighted the pivotal role of Th17 cells in the pathogenesis of UC (Fitzpatrick et al., 2020

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This approach is not part of the FDA-approved protocol, but it has a logical pharmacological basis and is gaining traction in clinical practice