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Gastroenterology 132, 19251936
Leptin resistance where the hypothalamus no longer responds appropriately to adipokine signals is a hallmark of established obesity, as described in StatPearls (NCBI)
10.1152/ajpendo.90887.2008 39
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Other, smaller trials in patients who already have Alzheimers point both ways, with Edison et al reporting better executive scores and less temporal and whole-brain atrophy on liraglutide, while Gejl (n=38, 6 mo follow-up) and Mullins (n=21, 1.5 yrs follow-up) were neutral to negative, which is exactly what you expect from studies that are short, and not powered to read a slow, insidious disease
