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Folate should be supplemented with it, particularly to help prevent colorectal cancer, which this drug otherwise promotes (Patel 2009

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Specifically, inhibiting or depleting spinal microglia abolished the anti-allodynic effects of morroniside, while neutralizing IL-10 or -endorphin with targeted antibodies, or blocking the -opioid receptor, fully reversed morroniside-induced mechanical anti-allodynia [74]